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Biochemistry
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Sep 15
A scientist working in a research laboratory has been examining different agonists of serotonin receptor 1B (5-HT1B), a G-protein-coupled re- ceptor. Compound A has a much higher affin- ity for 5-HT1B than compound B. Both com- pounds have a higher affinity for the receptor than serotonin. Which of the following de- scribes the relationship between compound A and compound B when considering the guan- ine-nucleotide exchange activity of 5-HT1B?
usmle
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Biochemistry
asked
Sep 15
As increased intracellular calcium is detrimen- tal to the cell, calcium homeostasis is tightly regulated both across the cell membrane and within the cell via sequestration in the en- doplasmic reticulum and mitochondria. In which of the following ways does increased intracellular calcium concentration cause the most cell damage?
usmle
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Biochemistry
asked
Sep 15
A 45-year-old white woman presents to her physician complaining of several months of worsening shortness of breath. Previously she was told she had asthma because she was hav- ing intermittent episodes of wheezing com- bined with a productive cough and difficulty catching her breath. She used to run two miles every morning but can no longer walk more than 10 city blocks without stopping. She has never smoked. On physical examination she is using her accessory muscles to assist with res- piration. Pulmonary examination is notable for an increased decreased FEV1/FVC ratio, decreased air movement with each breath, and increased resonance upon percussion. X-ray of the chest is shown in the image. Which of the following is the most likely underlying cause for this patient’s disease?
usmle
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2.6k
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Biochemistry
asked
Sep 15
A nucleic acid fragment is added to four dif- ferent tubes along with a polymerase, a radio- labeled primer, and deoxynucleotides. Each tube also contains one of the four bases as dideoxynucleotides. The four tubes are then run on electrophoresis gel and visualized by autoradiography. For which of the following purposes would the described laboratory tech- nique be utilized?
usmle
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Biochemistry
asked
Sep 15
A 57-year-old woman visits her primary care physician. Laboratory studies reveal an LDL of 194 mg/dL and HDL of 41 mg/dL. Her phy- sician begins therapy with a drug that inhibits production of mevalonic acid. Which of the following is a common side effect of this ther- apy?
usmle
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by
admin
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2.6k
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Biochemistry
asked
Sep 13
A patient who is a carrier of sickle cell trait presents to the clinic. The single base-pair mu- tation for sickle cell anemia destroys the MstII restriction enzyme recognition site represented by an asterisk in the image. The restriction enzyme-binding sites are shown as arrows on the map. DNA from this patient is treated with MstII and run on an electrophoresis gel. The DNA is then hybridized with a labeled probe that binds to the normal gene in the posi- tion shown on the map. In the Southern blot shown in the image, which lane represents the patient?
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Biochemistry
asked
Sep 13
A metabolic process is pictured below. Which intermediate in this process inhibits the rate- limiting enzyme of glycolysis and activates the rate-limiting enzyme of fatty acid synthesis?
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Physiology
asked
Aug 31
A 65-year-old male presents with a chronic cough that has progressively worsened over the past three months.
pulmonology
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2.6k
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Anatomy
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Aug 31
A 67-year-old man presents to the office with complaints of abdominal pain
anatomy
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Anatomy
asked
Aug 31
An ECG shows ST-segment elevation. A diagnosis of myocardial infarction is made
usmle
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Anatomy
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Aug 31
A 40-year-old woman is brought to the emergency department
anatomy
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Anatomy
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Aug 31
The newborn of a mother with poor antenatal care is found to have a larger-than-normal head
anatomy
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Anatomy
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Aug 31
A 50-year-old man presents to his primary care
anatomy
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Anatomy
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Aug 31
An 86-year-old woman is brought to the emergency
anatomy
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Anatomy
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Aug 31
A 72-year-old woman presents with left lower limb swelling.
anatomy
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Anatomy
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Aug 31
A 31-year-old woman presents to the clinic with shortness of
anatomy
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Anatomy
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Aug 31
A 59-year-old truck driver presents to the emergency department after returning from his usual week-long trucking
anatomy
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Anatomy
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Aug 31
A professional musician visits his physician after a morning concert. He complains of painless swelling
anatomy
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Physiology
asked
Aug 24
aiims pyq 2020
pyq
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Physiology
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Aug 24
aiims pyq 2020
pyq
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