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A 57-year-old woman visits her primary care physician. Laboratory studies reveal an LDL of 194 mg/dL and HDL of 41 mg/dL. Her phy- sician begins therapy with a drug that inhibits production of mevalonic acid. Which of the following is a common side effect of this ther- apy?

  1. (A)  Hepatomegaly without elevations in aspar- tate aminotransferase or alanine amino- transferase

  2. (B)  Muscle injury clinically similar to myositis

  3. (C)  Spontaneous abortion of a pregnancy

  4. (D)  Suicidality and homicidality in patients

    with bipolar disorder

  5. (E)  Tonic-clonic seizures

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