As increased intracellular calcium is detrimen- tal to the cell, calcium homeostasis is tightly regulated both across the cell membrane and within the cell via sequestration in the en- doplasmic reticulum and mitochondria. In which of the following ways does increased intracellular calcium concentration cause the most cell damage?
(A) Enzyme activation
(B) Free radical generation
(C) Increased membrane permeability
(D) Inhibition of glycolysis
(E) Inhibition of oxidative phosphorylation