A scientist working in a research laboratory has been examining different agonists of serotonin receptor 1B (5-HT1B), a G-protein-coupled re- ceptor. Compound A has a much higher affin- ity for 5-HT1B than compound B. Both com- pounds have a higher affinity for the receptor than serotonin. Which of the following de- scribes the relationship between compound A and compound B when considering the guan- ine-nucleotide exchange activity of 5-HT1B?

Question

A scientist working in a research laboratory has been examining different agonists of serotonin receptor 1B (5-HT1B), a G-protein-coupled re- ceptor. Compound A has a much higher affin- ity for 5-HT1B than compound B. Both com- pounds have a higher affinity for the receptor than serotonin. Which of the following de- scribes the relationship between compound A and compound B when considering the guan- ine-nucleotide exchange activity of 5-HT1B?

by admin (2.6k points) in Biochemistry asked Sep 15

(A) Km for the exchange reaction with com- pound A is higher than that with com- pound B
(B) Km for the exchange reaction with com- pound A is lower than that with compound B
(C) Km values with compounds A and B are the same
(D) The maximum reaction rate with com- pound A is greater than that with com- pound B
(E) The maximum reaction rate with com- pound B is greater than that with com- pound A

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