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Biochemistry
answered
Sep 10
A 6-year-old boy presents to his pediatrician with skin lesions all over his body. For several years he has been very sensitive to sunlight. Neither the boy’s parents nor his siblings have the same skin lesions or sun sensitivity. Biop- sies of several of the boy’s lesions reveal squa- mous cell carcinoma. Which mutation would one expect to see in this patient’s DNA?
usmle
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Sep 9
A 2-month-old boy is brought to the emer- gency department with respiratory insuffi- ciency and failure to thrive. The pregnancy and perinatal course were uneventful. Gener- alized hypotonia, tongue fasciculations, and flaccid paralysis are noted on physical exami- nation. His hospital stay is complicated by the development of tracheobronchomalacia and respiratory insufficiency that necessitates me- chanical ventilation. Despite these efforts, the patient dies of respiratory complications. Muscle biopsy shows denervation and panfas- cicular atrophy. A genetics consult yields the pedigree shown in the image. Which of the following diseases is most consistent with this patient’s presentation and the pedigree shown in the image?
general
principles
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Sep 9
A new screening test for the development of mitral regurgitation in the setting of rheumatic fever is created. A study of 1000 patients with a history of Streptococcus pyogenes infection and a diagnosis of rheumatic fever is performed using this test, which has 90% sensitivity and 85% specificity. The prevalence of mitral re- gurgitation in this population is estimated to be 40%. What is the positive predictive value of this test?
general
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Sep 9
A 66-year-old man presents to his primary care physician with a complaint of erectile dysfunc- tion. His past history is significant for hyper- tension, type 2 diabetes mellitus, peripheral vascular disease, and coronary artery disease status postmyocardial infarction. His current medications are propranolol, captopril, aspirin, lovastatin, metformin, fluoxetine, and sublin- gual nitroglycerin. On further questioning, he admits to wanting a prescription for sildenafil. Which of his medications is unsafe to take with sildenafil?
general
principle
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Sep 9
A 17-year-old girl presents to her primary care physician with a complaint of missed menses. A urine pregnancy test confirms that she is pregnant. She returns to the office two weeks later asking for recommendations on obtaining an abortion. She explains that she works, lives with her husband, and is not ready for a child. She decides that she does not want to notify anyone, and says she has chosen not to talk with her parents for many months. Her doctor understands that he must abide by her wishes because she is emancipated. Which of the fol- lowing makes this patient emancipated?
usmle
generalprinciple
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Sep 9
A group of scientists decides to conduct a study addressing the long-term effects of maternal alcohol consumption on their infants after conception. Two hundred women, including those who suffer from alcoholism and those who do not, are recruited into the study when they present for their first primary care visit. A medical history is taken on alcohol use, prena- tal care, nutritional status, and smoking behav- iors; these are measured monthly during the pregnancy. The researchers follow the wom- en’s pregnancies until term, after which they devote their attention to the health and behav- iors of the offspring. Which of the following is the most appropriate statistic the research- ers will be able to calculate as a result of their study?
usmle
general
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general principle
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Sep 9
An 11-year-old girl is brought to the pediatri- cian with complaints of back pain. On physical examination, a right thoracic scoliotic curve is noted. The pediatrician mentions to the parent that the development of adolescent idiopathic scoliosis is due to the girl being at peak height growth velocity. Peak height velocity is associ- ated with a certain Tanner stage; what other physical attributes would one expect to occur in this girl at the same time?
usmle
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general principle
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Sep 9
A 10-year-old Hispanic boy is admitted for bone marrow transplantation as treatment for acute myelogenous leukemia. The doctor wants to enroll the patient in a clinical trial for a new pain medication, but both the par- ents speak only Spanish. The consent form is in English, and the physician has a limited knowledge of Spanish. What is the physician’s best option for obtaining consent from this pa- tient?
usmle
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general principle
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Sep 9
A 70-year-old man comes into his doctor’s of- fice for a routine check-up. His past medi- cal history is significant for a heart attack, for which he takes a daily baby aspirin and a b-blocker. He practices safe habits and always wears his seat belt while driving. His health has been “great” for the past few years, al- though he is concerned about his wife because she recently suffered a mild stroke. He denies any visual loss or motor or sensory weakness. The patient’s physical examination is unre- markable. Which of the following is the lead- ing cause of death among people age 65 years or older?
usmle
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general principle
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Sep 9
A 54-year-old man with a history of poorly con- trolled hypertension complains of new-onset headaches. His mother passed away at an early age due to a stroke, and his father died of a myocardial infarction. When asked why he does not take better care of his blood pressure, he states that he is so busy with work and with the church that, by the end of the day, he often forgets to take his pills. He states that he “feels fine, anyway.” What ego defense mechanism is this patient using?
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general principle
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Sep 9
A 3-year-old girl presents for her regular check- up. Her mother reports that she is fully toilet trained, and that she can dress and undress with minor assistance. She speaks in full sen- tences, can name four colors, and can copy a simple circle drawing. What other milestone would this child most likely have reached since her last visit one year ago?
usmle
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general principle
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Sep 9
A retrospective cohort study is examining birth complications in women with diabetes. The study determines that babies are more likely to be born large for gestational age (LGA) if the mother has diabetes. The relative risk for the study is calculated to be 4. Which of the fol- lowing accurately describes this relative risk?
usmle
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general principle
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Sep 9
A 45-year-old man presents to a psychiatrist at his wife’s prompting. He is an English profes- sor at the University of Virginia and regularly wins accolades for his well-organized and ar- ticulate lectures. In the past three months, he has become convinced that his wife is having an affair with a co-worker, despite her protests to the contrary. His wife recently discovered that he hired a private investigator to track her whereabouts. He is very defensive when the counselor questions his suspicions about his wife. Mental status examination reveals a well- dressed, middle-aged man without hallucina- tions or other mood disturbances. His speech is normal and displays an appropriate affec- tive range. Which of the following is the most likely diagnosis?
usmle
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Sep 5
A 6-year-old girl is brought to the pediatrician by her mother because of fecal incontinence. The mother says this behavior usually occurs at school. According to Freud, which stage of psychosexual development has this child failed to progress through?
usmle
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Sep 5
A 28-year-old woman presents to her primary care physician because of depressed mood. She states that she has been depressed for as long as she can remember and feels bad about herself almost all of the time. She states that her only happy moments were during her hon- eymoon two years ago, and during a ski trip in college when she felt “on top of the world.” She confides that for a couple weeks last month she felt life was no longer worth living. At that time, she was having extreme difficulty
usmle
high
yield
principle
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Sep 5
A 28-year-old woman presents to her primary care physician because of depressed mood. She states that she has been depressed for as long as she can remember and feels bad about herself almost all of the time. She states that her only happy moments were during her honeymoon two years ago, and during a ski trip in college when she felt “on top of the world.” She confides that for a couple weeks last month she felt life was no longer worth living. At that time, she was having extreme difficulty
usmle
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Sep 5
A 52-year-old woman is being treated by a male psychiatrist for depression stemming from her recent divorce. Recently, the patient has been coming to her appointments dressed up and wearing expensive perfumes. She has also started to flirt with the doctor. The patient’s demeanor and appearance had initially reminded the psychiatrist of his aunt. He is uncomfortable with the patient’s new behavior patterns and tells her so. She becomes very angry and storms out of the office, canceling all remaining appointments on her way out. Which of the following behaviors is an example of negative transference?
usmle
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Sep 5
A 16-year-old boy is brought to the pediatrician by his mother because of excessive daytime sleepiness. She states that over the past six months she has received numerous phone calls from the boy’s school informing her that her son sleeps throughout all of his afternoon classes and is often difficult to arouse at the end of class.
usmle
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Sep 5
Researchers investigating the development of the idiopathic inflammatory myopathies (IIMs) such as polymyositis read that vitamin D may act as an immunomodulator that reduces the development and severity of autoimmune diseases. Given that many Americans are vitamin D deficient, the researchers design an observational study to assess the impact of vitamin D supplementation on IIM symptom severity. Subjects are surveyed at time 0 and after two years, and the results are listed in the chart. Which equation represents the chance of symptom improvement in subjects who took vitamin D supplements relative to subjects who did not take vitamin D supplements?
general
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Aug 31
A 45-year-old male presents to the clinic with a six-month history of progressively worsening shortness of breath, especially on exertion. He also complains of a persistent dry cough and fatigue.
pulmonology
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