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A 20-year-old man became very agitated at a party, and as a result was brought to the emergency department. In the waiting room he is belligerent and uncooperative. A physical examination reveals fever, tachycardia, horizontal nystagmus, hyperacusis, and pupils that are 3 mm in diameter bilaterally. Which of the following substances is most likely causing the behavioral changes and physical findings exhibited by this patient?

(A) Alcohol

(B) Amphetamines

(C) Cocaine

(D) Lysergic acid diethylamide

(E) Nicotine

(F) Phencyclidine
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Best answer

The correct answer is F. This patient has taken phencyclidine, or PCP. Patients with PCP intoxication show signs of belligerence,impulsiveness, fever, psychomotor agitation,vertical and horizontal nystagmus, tachycardia,ataxia, homicidality, psychosis, and delirium.On withdrawal, patients may demonstrate a recurrence of intoxication when the PCP, which was trapped in an ionized form in the acidic gastric lumen, is reabsorbed in the alkaline duodenum. PCP users will have normal or small pupils. Death can result from a variety of causes, including respiratory depression and violent behavior.

Answer A is incorrect. Patients presenting with acute alcohol intoxication will show symptoms of disinhibition, emotional lability, slurred speech, ataxia, coma, and blackouts. On withdrawal, they will demonstrate a tremor, tachycardia, hypertension, malaise, nausea, seizures,delirium tremens, tremulousness, agitation and hallucinations.

Answer B is incorrect. Patients presenting with amphetamine intoxication will display psychomotor agitation, impaired judgment,pupillary dilation, hypertension, tachycardia,euphoria, prolonged wakefulness and attention, cardiac arrhythmias, delusions, hallucinations, and fever. On withdrawal, they will show a post-use “crash” that includes depression,lethargy, headache, stomach cramps, hunger and hypersomnolence.

Answer C is incorrect. Patients presenting with acute cocaine intoxication will show symptoms of euphoria, psychomotor agitation, impaired judgment, tachycardia, pupillary di- lation, hypertension, hallucinations, paranoid ideations, angina, and sudden cardiac death. On withdrawal, they will show a post-use “crash” that includes severe depression, hyper- somnolence, fatigue, malaise, and severe psy- chological craving.

Answer D is incorrect. Patients presenting with acute lysergic acid diethylamide intoxication will display marked anxiety or depression,delusions, visual hallucinations, flashbacks and pupillary dilation.

Answer E is incorrect. Patients presenting with acute nicotine intoxication will show symptoms of restlessness, insomnia, anxiety and arrhythmias. On withdrawal, they will have symptoms of irritability, headache, anxiety, weight gain, craving, and tachycardia.

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