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A 42-year-old woman presents to her physician with generalized itching. Physical examination reveals scleral icterus. Laboratory tests show: Total bilirubin: 2.7 mg/dL Conjugated bilirubin: 2.4 mg/dL Alkaline phosphatase: 253 U/L Aspartate aminotransferase: 36 U/L Alanine aminotransferase: 40 U/L What is the most likely mechanism underlying this patient’s jaundice?

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by (2.6k points) in Biochemistry

A 42-year-old woman presents to her physician with generalized itching. Physical examination reveals scleral icterus. Laboratory tests show:

  • Total bilirubin: 2.7 mg/dL 
  • Conjugated bilirubin: 2.4 mg/dL
  •  Alkaline phosphatase: 253 U/L 
  • Aspartate aminotransferase: 36 
  • U/L Alanine aminotransferase: 40 U/L

What is the most likely mechanism underlying this patient’s jaundice?

  1. (A)  Absence of UDP-glucuronyl transferase

  2. (B)  Decreased levels of UDP-glucuronyl trans- ferase

  3. (C)  Extravascular destruction of the patient’s RBCs

  4. (D)  Intrahepatic or extrahepatic biliary obstruction

  5. (E)  Intravascular destruction of the patient’s RBCs

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