Hemoglobin consists of four polypeptide sub- units: two a subunits and two b subunits. The arrangement of these subunits shifts between a taut and relaxed conformation, resulting in changes in hemoglobin’s oxygen affinity. At a given partial pressure of oxygen, which of the following will decrease hemoglobin’s affinity for oxygen?

Question

Hemoglobin consists of four polypeptide sub- units: two a subunits and two b subunits. The arrangement of these subunits shifts between a taut and relaxed conformation, resulting in changes in hemoglobin’s oxygen affinity. At a given partial pressure of oxygen, which of the following will decrease hemoglobin’s affinity for oxygen?

by admin (2.6k points) in Biochemistry asked Sep 15

(A) Decreasing the partial pressure of carbon dioxide
(B) Increasing the amount of 2,3-bisphospho- glycerate in RBCs
(C) Increasing the number of oxygen mole- cules bound to a hemoglobin from one to three

(D) Increasing the pH by moving from periph- eral tissue to lung

(E) The presence of excess carbon monoxide

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